Computational Mitochondrial PsychoBiology

Saggar M, Picard M .

Aims

By carefully studying the spatiotemporal dynamical patterns of communications between mitochondria, we aim to ultimately quantify energetic disturbances years before they manifest on a scan or in blood work into disease.

Highlights

  • We recently examined the association between multiple features of mitochondrial health and stress-related behaviors in mice with diverse behavioral phenotypes
  • Multi-slice network analysis applied to our brain-wide mitochondrial dataset identified three large-scale networks of brain regions with shared mitochondrial signatures.
  • Mito-based networks also overlap with regional gene co-expression and structural connectivity, thereby providing convergent multimodal evidence of mitochondrial functional organization anchored in gene, brain and behavior.

Presentations/Papers

  1. Rosenberg, A., Saggar, M., Rogu, P., Sandi, C., Dumitriu, D., Anacker, C., Picard, M. Mitochondrial Health in Mouse Cortical and Sub-cortical Brain Region Networks is Linked to Behavior .

Funding

Philanthropic support