Aims
By carefully studying the spatiotemporal dynamical patterns of communications between mitochondria, we aim to ultimately quantify energetic disturbances years before they manifest on a scan or in blood work into disease.
Highlights
- We recently examined the association between multiple features of mitochondrial health and stress-related behaviors in mice with diverse behavioral phenotypes
- Multi-slice network analysis applied to our brain-wide mitochondrial dataset identified three large-scale networks of brain regions with shared mitochondrial signatures.
- Mito-based networks also overlap with regional gene co-expression and structural connectivity, thereby providing convergent multimodal evidence of mitochondrial functional organization anchored in gene, brain and behavior.
Presentations/Papers
- Rosenberg, A., Saggar, M., Rogu, P., Sandi, C., Dumitriu, D., Anacker, C., Picard, M. (2021) Mitochondrial Health in Mouse Cortical and Sub-cortical Brain Region Networks is Linked to Behavior .
- Rosenberg, A., Saggar, M., Rogu, P., Sandi, C., Dumitriu, D., Anacker, C., Picard, M. (2023) <a href=> Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice.</a> Nature Communications
Funding
Philanthropic support